AB092. Comparison of quercetin and resveratrol in the prevention of injury due to testicular torsion/detorsion in rats

Background: Quercetin (QE) and resveratrol (RSV) are powerful antioxidants with the potential to protect the testes against ischemia/reperfusion (I/R) injury. We compared their effects in testicular torsion/detorsion (T/D) in adult rats.

Methods: Twenty-four male Wistar rats were divided in four groups: A, B, C, and D. QE and RSV were injected intra-peritoneally. After torsion, the testicular cord was restored. After torsion, blood and tissue samples were obtained.

Results: MDA and NO levels, TOS and TAS were higher in group B. QE and RSV lowered MDA, NO, and TOS levels and TAS consumption. QE reduced the MDA and TOS levels more than RSV. Groups C and D had lower testicular injury grade. Group C had lower testicular injury grade

Conclusions: Treatment with QE and RSV protects against I/R injury after testicular T/D. QE may exhibit better function than RSV at the doses tested in this study.

Keywords: Ischemia/reperfusion (I/R); quercetin (QE); resveratrol (RSV); testicular torsion/detorsion (T/D)