AB047. Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study

Background: To clarify the potential role of fluid intake-to-bed time and nocturia frequency on bladder cancer (BCa) risk in a hospital-based case-control study with Chinese people.

Methods: 407 patients with histologically diagnosed BCa and 400 matched controls were enrolled in this study. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression model.

Results: The fluid intake-to-bed time was associated with a decreased risk of BCa, with an OR of 0.586 (95% CI: 0.375–0.916, ≤1 h) and 0.257 (95% CI: 0.162–0.407, >1 h). The adjusted ORs of BCa for subjects with more nocturia frequency were 2.268 (95% CI: 1.481–3.474), compared to those with no nocturia.

Conclusions: We suggested strong protective effect of long fluid intake-to-bed time on BCa risk, especially in ones with ≥2 times nocturia frequency. These results provide evidence for identifying high-risk individuals and modifying their behavior and lifestyle.

Keywords: Bladder cancer (BCa); case-control study; fluid intake-to-bed time; nocturia