Antioxidants for elevated sperm DNA fragmentation: a mini review

Ahmad Majzoub, Ashok Agarwal, Sandro C. Esteves


We would like to thank Dr. Cho for his insightful commentary on our article discussing the utility of sperm DNA fragmentation (SDF) testing for fertility evaluation (1). The author elegantly summarized the principle concepts of the article and provided his expert views of the topic. Dr. Cho rightly commented that “One of the major huddles of clinical application of a test lies in the lack of treatment modalities. And the development of treatment strategies, e.g., the use of antioxidants and sperm selection methods, must go hand in hand with advancement of sperm DNA testing which was also included in the guideline.” We certainly agree with his view on this point, especially since SDF testing has been criticized based on the unavailability of effective treatment modalities. In reply, we would like to highlight the existing available evidence on antioxidant use in patients with high SDF.