The correct interpretation of sperm DNA fragmentation test

Chak-Lam Cho, Ashok Agarwal, Ahmad Majzoub, Sandro C. Esteves


We read the commentary by Dr. Ferlin with interest (1). The author first stated the drawbacks of semen analysis in the diagnosis of male infertility and the need for sperm function tests. It is followed by illustrating the limitation of the current evidence in supporting the routine use of sperm DNA fragmentation (SDF) testing in clinical practice.