Evidence based sperm DNA fragmentation

Male factor infertility is an important and current issue in the field of human reproduction. The prevalence of male factor associated infertility is increasing with almost 50% of all cases of fertility treatments being linked to this factor (1). Moreover, the introduction of intracytoplasmic sperm injection (ICSI) in 1992 (2) offered, for patients with severe male factor infertility, the opportunity of conception and allowed the scientific community to better understand not only the aspects of male factor but also the accurate indications for ICSI (3).