Call for wider application of sperm DNA fragmentation test

Ashok Agarwal, Chak-Lam Cho, Ahmad Majzoub, Sandro C. Esteves

Abstract

Dr. Khandwala and Dr. Eisenberg in their insightful commentary discussed and endorsed the role of sperm DNA fragmentation (SDF) testing under specific circumstances in clinical practice (1). We concur with the authors that properly designed comparative studies, though ideal in providing the best quality evidence, are difficult to conduct in delineating the role of SDF testing in male infertility management.