Utility of testing sperm DNA fragmentation: an all-in-one diagnostic tool to address a multi-pronged clinical problem

In a comprehensive clinical overview, Agarwal et al. (1) nicely put in perspective (I) various laboratory techniques used for testing sperm DNA fragmentation (SDF), a commonly encountered aberration in the sub-fertile/infertile male, (II) underscore the importance of careful assessment of this parameter in the context of several clinical scenarios of reproductive failure, and (III) recommend the utility of these techniques in identifying the underlying cause with emphasis on its particular relevance to clinical varicoceles in men.