AB305. SPR-32 Aging effects on the central motor control of the external anal sphincter in women
Abstract

AB305. SPR-32 Aging effects on the central motor control of the external anal sphincter in women

Yun Peng1, Jinbao He2, Rose Khavari3,4, Timothy B. Boone3,4, Yingchun Zhang1

1Department of Biomedical Engineering, University of Houston, Houston, TX, USA; 2Ningbo University of Technology, Ningbo 315032, China; 3Regenerative Medicine Program, Houston Methodist Research Institute, Houston, TX, USA; 4Department of Urology, Houston Methodist Hospital, Houston, TX, USA


Objective: Accumulated clinical evidence has shown that aging is associated with deficits in the central nerve system (CNS) that leads to disruption in descending excitation. Whether this is true in pelvic floor muscles remains unclear. This study aimed to study whether there is evidence of an aging-associated decreasing descending excitation to the motoneuron pool of the external anal sphincter (EAS) in women.

Methods: Surface electromyography (EMG) signals of the EAS were acquired from 14 female subjects (38.6±16.6 years, range: 20–73 years, no anorectal disorders) during maximum squeeze using a high-density rectal probe. Motor unit (MU) action potentials were separated using our K-means clustering and convolution kernel compensation algorithm, with the firing rate of each MU obtained. The mean MU firing rate, a key marker to assess the motor control of the CNS, was calculated for all decomposed MUs for each subject. Linear regression analysis was performed to study the impact of aging on the mean MU firing rate.

Results: The mean MU firing rate was 7.4±2.1 Hz. Linear regression showed a decreasing, though not significant, trend with advancing age (P=0.10), suggesting a possible deficit in the CNS of aged women in driving the lower motoneurons to activate the EAS. Our ongoing recruitment of more aged women will help us consolidate this observation, to offer valuable insights into the mechanism of aging-associated anorectal disorders.

Conclusions: This study represents the first effort to use advanced high-density surface EMG analysis to noninvasively evaluate aging effects on the central motor control of the EAS in women.

Funding Source(s): NIH DK082644 and the University of Houston

Keywords: External anal sphincter (EAS); aging; electromyography (EMG); device development; neural plasticity


doi: 10.21037/tau.2016.s305


Cite this abstract as: Peng Y, He J, Khavari R, Boone TB, Zhang Y. Aging effects on the central motor control of the external anal sphincter in women. Transl Androl Urol 2016;5(Suppl 2):AB305. doi: 10.21037/tau.2016.s305

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