AB258. Effect and mechanism of grape seed proanthocyanidin extract (GSPE) on diabetes-induced bladder dysfunction

Background: To explore the effect and mechanism of grape seed proanthocyanidin extract (GSPE) on diabetes-induced bladder dysfunction.

Methods: Female Wistar rats was divided into 3 groups at random: Control group, STZ induced diabetes group and GSPE administrated diabetic group. Urodynamic method was used to examine the bladder pressure of the rats. The quantity of MDA and the activities of SOD and GSH-Px was examined by related assay.

Results: Compared with the control group, the bladder contraction pressure in diabetic group decreased and after GSPE administration, the bladder function of the diabetic rats was improved significantly (P<0.05). The bladder structure in diabetic group was damaged and some inflammatory cells infiltration and GSPE could improve it. Compared with the control group, the quantity of MDA was increased and the activities of SOD and GSH-Px were decreased in diabetic group (P<0.05) while GSPE could reverse the changes of MDA, SOD and GSH-Px.

Conclusions: GSPE could ameliorate diabetic bladder dysfunction which may be associated with its antioxidant activities.

Keywords: Diabetic bladder; grape seed proanthocyanidin extract (GSPE)