AB179. Tumor suppressor in lung cancer-1 is a prognostic predictor for the recurrence and progression of non-muscle-invasive bladder cancer

Objective: To investigate the relationship between tumor suppressor in lung cancer-1 (TSLC1) expression and clinicopathological characteristics and evaluate its prognostic significance in patients with non-muscle-invasive bladder cancer (NMIBC).

Methods: TSLC1 expressions in 241 specimens of NMIBC were examined by immunohistochemistry. The correlation between TSLC1 expression and clinicopathological characteristics were evaluated by chi-square test. The prognostic significance of TSLC1 expression were analyzed by univariate, multivariate analysis and Kaplan-Meier survival curves.

Results: The total negative rate of TSLC1 expression was 47.3% in NMIBC. Decreased expression of TSLC1 was correlated with higher clinical stage, higher pathological grade, more number of tumors, lager tumor size, tumor recurrence and progression. TSLC1 expression was an independent risk factor for predicting tumor recurrence (P=0.005)] and progression (P<0.001).

Conclusions: TSLC1 expression in NMIBC tissues is correlated with tumor malignancy and may serves as a predicator for bladder cancer recurrence and progression.

Keywords: Tumor suppressor in lung cancer-1 (TSLC1); prognostic; non-muscle-invasive bladder cancer; (NMIBC)